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KOL Meeting Preparation Using Perplexity Deep Research

Prompt provided by Patrina Pellet, PhDYou are a seasoned senior MSL with deep expertise in identifying what different Key Opinion Leaders (KOLs) value most in order to build long-term, trust-based relationships. I need your strategic insight to help me prepare for an upcoming meeting with a KOL. Here’s what I know so far:
• KOL Name: Ola Landgren
• Institution: University of Miami
• Area of Expertise: Myeloma
• Relevant Publication(s):
Lancet Oncol. 2014 Nov;15(12):e538-48. doi: 10.1016/S1470-2045(14)70442-5. Epub 2014 Oct 26.
Lancet Oncol. 2016 Aug;17(8):e328-e346. doi: 10.1016/S1470-2045(16)30206-6.
Blood. 2015 May 14;125(20):3069-75. doi: 10.1182/blood-2014-09-568899. Epub 2015 Apr 2.
N Engl J Med. 2022 Sep 29;387(13):1196-1206. doi: 10.1056/NEJMoa2209900.
J Clin Oncol. 2024 Apr 10;42(11):1229-1240. doi: 10.1200/JCO.23.01277. Epub 2024 Jan 9.
Nat Med. 2023 Sep;29(9):2295-2306. doi: 10.1038/s41591-023-02491-5. Epub 2023 Aug 31. Based on this, please provide thoughtful, high-level guidance on the following:

1. Motivations & Drivers
What are this KOL’s likely core motivations? For example, if they are heavily involved in clinical research, what specific interests or goals might they have (e.g., innovation, trial design, translational science, patient outcomes)?
2. Pain Points & Challenges
What are the likely challenges or unmet needs they face within their area of expertise?
3. Emerging Topics & Trends
What trends, disruptive technologies, or emerging research areas are most likely to capture their attention based on their current work?
4. Value-Add Opportunities
What types of data, resources, insights, or support could I offer to meaningfully support their goals and build credibility?
5. Personalized Engagement
How can I tailor my communication and engagement style to align with their professional values and preferences?
6. Conversation Starters
What topics or insights from their recent publications or public presentations would serve as strong conversation openers?
7. Strategic Relationships
Who might be their key collaborators, influencers, or professional network nodes—and how might I reference or leverage those connections?
8. Communication Style Alignment
Based on their presentation, writing, or interview style, how should I adapt my tone, language, or pacing?
9. Post-Meeting Follow-Up
What follow-up actions or touchpoints could I take to remain visible and valuable after the meeting?
10. Personal Touchpoints
Are there any known non-professional interests, causes, or affiliations I could authentically reference to help build rapport?

Results from Perplexity Deep Research

Strategic Insights for Meeting with Dr. Ola Landgren

  1. Motivations & Drivers

Dr. Ola Landgren is driven by innovation and the pursuit of curative approaches for multiple myeloma. His work emphasizes early detection, prevention, and precision medicine to optimize patient outcomes and quality of life[1][2][3]. He is deeply invested in translational research, such as using minimal residual disease (MRD) as a clinical endpoint to accelerate drug development timelines[4][3]. His focus on chemotherapy-free regimens and immunotherapies highlights his commitment to advancing treatment paradigms[5].

  1. Pain Points & Challenges

Key challenges in Dr. Landgren’s field include:

  • The need for better biomarkers to identify high-risk patients accurately and optimize therapies[6].
  • Developing curative therapies for multiple myeloma despite significant advances in survival rates[6][3].
  • Addressing unmet needs in managing smoldering myeloma and preventing progression to active disease[7].
  • Bridging gaps between academic and community care centers to ensure seamless transitions for patients undergoing complex therapies like CAR-T cells or stem cell transplants[8].
  1. Emerging Topics & Trends

Dr. Landgren is likely interested in:

  • Advances in immunotherapy, including bispecific/trispecific antibodies and CAR-T cell therapies, which are reshaping the standard of care[6][5].
  • Research into genetic precursors for myeloma, enabling preventive strategies[2][7].
  • Precision medicine approaches that tailor treatments based on individual patient profiles[3].
  • MRD-guided treatment strategies and their broader implications for other cancers[4].
  1. Value-Add Opportunities

You can support Dr. Landgren’s goals by:

  • Providing real-world data on treatment outcomes, especially in high-risk or smoldering myeloma populations[9].
  • Offering insights into emerging technologies like immune imaging or circulating tumor DNA assays that align with his research interests[2].
  • Facilitating connections with regulatory bodies or industry partners to expedite clinical trial designs focused on MRD endpoints[4].
  • Sharing updates on global collaborations or innovations in immunotherapy and precision medicine.
  1. Personalized Engagement

Tailor your communication by:

  • Acknowledging his leadership role and contributions to advancing myeloma research.
  • Demonstrating a deep understanding of his recent publications and ongoing trials.
  • Engaging him on topics he values, such as curative strategies, MRD applications, or chemotherapy-free regimens.
  1. Conversation Starters

Potential conversation openers include:

  • Discussing findings from his recent Nature Medicine publication on genetic precursors of myeloma[1][2].
  • Exploring the implications of the EVIDENCE meta-analysis on MRD as a clinical endpoint for drug approvals[4].
  • Asking about the progress of trials like TRANSFORMM or ADVANCE and their impact on early intervention strategies[2].
  1. Strategic Relationships

Dr. Landgren collaborates extensively with institutions like Memorial Sloan Kettering Cancer Center, Mayo Clinic, and international organizations such as the International Myeloma Foundation[4][3]. Mentioning these collaborations or referencing shared interests could strengthen rapport.

  1. Communication Style Alignment

Dr. Landgren values teamwork and collaboration, as reflected in his leadership philosophy of building programs “like a family”[3]. Use a conversational tone that emphasizes mutual goals and shared vision while maintaining professionalism. Active listening and thoughtful responses will resonate well.

  1. Post-Meeting Follow-Up

To maintain visibility:

  • Send a personalized thank-you email summarizing key discussion points.
  • Provide relevant resources or data that align with his research priorities.
  • Suggest follow-up opportunities, such as collaborating on upcoming trials or attending related conferences.
  1. Personal Touchpoints

Dr. Landgren’s Swedish roots and emphasis on global collaboration may provide opportunities to discuss international research efforts or cultural connections[3]. Additionally, referencing his leadership style or team-building philosophy could help build rapport authentically.

By aligning your approach with Dr. Landgren’s professional values, scientific priorities, and collaborative mindset, you can foster a meaningful relationship that supports his mission to transform outcomes in multiple myeloma care.

⁂

  1. https://umiamihealth.org/en/sylvester-comprehensive-cancer-center/accomplishment-reports/2021/investing-in-the-future/target,-c-,-multiple-myeloma-cure
  2. https://med.miami.edu/departments/medicine/divisions/myeloma/research
  3. https://news.med.miami.edu/qa-with-cancer-researcher-and-physician-dr-c-ola-landgren/
  4. https://news.med.miami.edu/multiple-myeloma-therapy-approval/
  5. https://www.cancernetwork.com/view/ola-landgren-md-phd-on-the-future-of-multiple-myeloma-research
  6. https://www.cancernetwork.com/view/treatment-options-and-unmet-needs-evaluated-in-multiple-myeloma
  7. https://www.cancer.org/cancer/types/multiple-myeloma/about/new-research.html
  8. http://www.curetoday.com/view/communication-is-key-when-transitioning-multiple-myeloma-care
  9. https://www.ashresearchcollaborative.org/multiple-myeloma-research-network/multiple-myeloma-program/